Multiple levels of nuclear organization contribute to genetic and epigenetic control in nuclerar microenvironments for biological control and tumorigenesis.

Genetic
– Localization of genes in nuclear microenvironments

Epigenetic
– Organization, assembly and strategic placement of regulatory machinery for histone and DNA modifications at proximal and distal gene promoter sites

– Retention of transcription factors at target gene loci for mitotic retention of cell fate and lineage commitment in progeny cells

Dr. Gary S. Stein, Chair Dept. of Biochemistry University of Vermont; Director University of Vermont Cancer Center

  

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Publicado el 2015, June 26
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